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Blood glucose meter performance under hyperbaric oxygen conditions.

D A Vote1, O Doar, R E Moon

  • 1Center for Hyperbaric Medicine and Environmental Physiology, Duke University Medical Center, Durham, NC 27710, USA. vote0001@mc.duke.edu

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 16, 2001
PubMed
Summary

The Precision PCx blood glucose meter shows significant inaccuracies at high oxygen levels compared to the SureStepPro meter. This impacts its reliability for accurate plasma glucose measurements in varied oxygen environments.

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Area of Science:

  • Biomedical Engineering
  • Clinical Chemistry

Background:

  • Accurate blood glucose monitoring is crucial for patient care.
  • Bedside glucose meters are widely used, but their accuracy can be affected by physiological factors.
  • High partial pressure of oxygen (P(O(2))) is a potential interfering factor in glucose meter performance.

Purpose of the Study:

  • To evaluate the accuracy of the Precision PCx (PCx) blood glucose meter.
  • To compare the PCx performance against the SureStepPro (SSP) meter, known for its stability at high P(O(2)).
  • To assess the impact of varying P(O(2)) on the accuracy of both meters.

Main Methods:

  • Human blood samples were used to create plasma glucose (PG) concentrations ranging from 25-300 mg/dl.
  • Samples were tonometered to achieve P(O(2)) levels of 1200 mmHg and 60 mmHg.

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  • PG measurements from PCx and SSP were compared at both P(O(2)) levels.

    • Main Results:

    • The SSP meter showed minimal variation (1.3 +/- 6.5 mg/dl) in PG readings between high (1200 mmHg) and low (60 mmHg) P(O(2)).
    • The PCx meter exhibited significant bias and imprecision at 60 mmHg (4.1 and 22.9 mg/dl, respectively).
    • At 1200 mmHg, the PCx meter's bias and imprecision increased substantially to 47.9 and 35.1 mg/dl, respectively.

    Conclusions:

    • The SureStepPro meter maintains accuracy across different oxygen levels.
    • The Precision PCx meter demonstrates significant inaccuracy and imprecision, particularly at high P(O(2)).
    • The PCx meter is not recommended for accurate plasma glucose measurement in environments with varying or high oxygen partial pressures.