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Related Experiment Videos

Formulation and process optimization to eliminate picking from market image tablets.

A Sabir1, B Evans, S Jain

  • 1Pharmaceutical Sciences, GlaxoWellcome Inc., Research Triangle Park, Durham, NC 27709, USA.

International Journal of Pharmaceutics
|March 16, 2001
PubMed
Summary
This summary is machine-generated.

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Tablet picking during compression was reduced by optimizing direct compression formulation and modifying tooling. Increasing embossed cut angles and controlling magnesium stearate and colloidal silicon dioxide levels created a robust manufacturing process.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Tablet picking is a common issue in direct compression manufacturing.
  • Existing tooling and formulations may not prevent powder adherence.

Purpose of the Study:

  • To optimize direct compression formulations and processes to minimize tablet picking.
  • To evaluate the impact of tooling modifications on picking.

Main Methods:

  • D-optimal statistical experimental design was used to investigate formulation variables (magnesium stearate, colloidal silicon dioxide) and lubrication time.
  • Compression was performed using original and modified tooling with altered embossed cut angles.
  • Statistical analysis identified robust manufacturing regions.

Main Results:

Related Experiment Videos

  • A robust manufacturing region was identified for formulations with 1-1.25% magnesium stearate and 0.1-0.3% colloidal silicon dioxide (CSD), with 5-10 min lubrication time using modified tooling.
  • Increasing embossed cut angles from 70 to 90 degrees significantly reduced picking.
  • CSD demonstrated a concentration-dependent effect on magnesium stearate lubrication efficiency and compactability.

Conclusions:

  • Modified compression tooling with increased cut angles is effective in reducing tablet picking.
  • Optimized formulation parameters and process controls are crucial for robust direct compression manufacturing.
  • Pre-blending CSD with the powder blend enhances magnesium stearate lubrication efficiency.