Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enhanceosomes.

M Merika1, D Thanos

  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.

Current Opinion in Genetics & Development
|March 16, 2001
PubMed
Summary
This summary is machine-generated.

Specific gene activation in eukaryotes relies on enhanceosomes, which are complex DNA-protein structures. These enhanceosomes ensure precise gene transcription by requiring all components to be present for activation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nucleosome sliding via TBP DNA binding in vivo.

Cell·2001
Same author

Coordination of a transcriptional switch by HMGI(Y) acetylation.

Science (New York, N.Y.)·2001
Same author

Overexpression of proteins HMGA1 induces cell cycle deregulation and apoptosis in normal rat thyroid cells.

Cancer research·2001
Same author

The IFN-beta enhancer: a paradigm for understanding activation and repression of inducible gene expression.

Cold Spring Harbor symposia on quantitative biology·2001
Same author

Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter.

Cell·2000
Same author

Gene repression by coactivator repulsion.

Molecular cell·2000
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Gene transcription in higher eukaryotes involves complex cis-acting elements.
  • Specificity in gene transcription is increasingly attributed to enhanceosomes.

Purpose of the Study:

  • To explore the role of enhanceosomes in gene-specific transcriptional regulation.
  • To understand the mechanism of enhanceosome assembly and function.

Main Methods:

  • The study reviews existing literature and theoretical models of enhanceosome function.
  • Analysis of co-operativity in enhanceosome assembly and synergistic transcription activation.

Main Results:

  • Enhancesomes are higher-order, three-dimensional transcription factor/enhancer DNA complexes.

Related Experiment Videos

  • Co-operativity in assembly and synergy in transcription ensure gene-specific activation.
  • Enhancesomes recruit chromatin modifiers and basal transcription factors to promoters.

    • Conclusions:

    • Enhancesomes provide a mechanism for precise, gene-specific transcriptional control.
    • The presence of all enhanceosome components is critical for activating gene transcription.