Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dosage compensation in birds.

H A McQueen1, D McBride, G Miele

  • 1Institute of Cell and Molecular Biology, The University of Edinburgh, EH9 3JR, Scotland, United Kingdom.

Current Biology : CB
|March 16, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Occupational exposures and sarcoidosis: a rapid review of the evidence.

Occupational medicine (Oxford, England)·2024
Same author

Constraints on Heavy Decaying Dark Matter from 570 Days of LHAASO Observations.

Physical review letters·2023
Same author

The contribution of personal audio system use and commuting by bus on daily noise dose.

Noise & health·2021
Same author

Paraneoplastic syndrome or immune-related adverse event? A case of rhomboencephalitis in a patient treated with Pembrolizumab.

Acta neurologica Belgica·2021
Same author

BMI influences CD20 kinetics in multiple sclerosis patients treated with ocrelizumab.

Multiple sclerosis and related disorders·2020
Same author

Heidenhain variant of Creutzefeldt-Jackob disease in a patient carrying the V210I mutation with asymmetric MRI abnormalities.

Acta neurologica Belgica·2020

Avian dosage compensation is a widely debated topic. This study reveals that most Z-linked genes in chicken embryos are dosage compensated, challenging previous assumptions.

Area of Science:

  • Genetics
  • Evolutionary Biology
  • Developmental Biology

Background:

  • Birds possess ZW sex chromosomes, with females being heterogametic (ZW) and males homogametic (ZZ).
  • Unlike mammals, birds were thought to lack dosage compensation, a mechanism that equalizes sex-linked gene expression.
  • Differential expression of Z-linked genes was proposed to be central to avian sex determination.

Purpose of the Study:

  • To investigate the presence and extent of dosage compensation for Z-linked genes in chicken embryos.
  • To challenge the prevailing view that birds lack dosage compensation.

Main Methods:

  • Utilized real-time quantitative PCR (qPCR) to measure the expression levels of nine Z-linked genes.
  • Compared gene expression between male (ZZ) and female (ZW) chicken embryos.

Related Experiment Videos

Main Results:

  • Found equivalent expression for at least six out of nine Z-linked genes in male and female embryos.
  • Identified the Z-linked ScII gene as an exception, showing differential expression (i.e., escaping compensation).

Conclusions:

  • The majority of Z-linked genes in chickens are dosage compensated, contrary to prior beliefs.
  • This finding has significant implications for understanding avian sex determination and evolution.