Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

New hurdles for translational research.

¹Academic Department of Biochemistry, Royal Marsden Hospital, London, UK. mitch@icr.ac.uk

Breast Cancer Research : BCR

|March 16, 2001

Summary

New human tissue research guidelines may hinder cancer research progress. Stricter ethical approval and patient consent rules for surplus tissues create unnecessary obstacles for translational research, particularly with emerging technologies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A new way of grading severity of ACL rupture on acute MRI to consider potential for non-surgical healing with the Cross Bracing Protocol: ACL Acute Rupture Characteristics for Healing (ACL-ARCH) MRI criteria.

Journal of science and medicine in sport·2025

Same author

Relationship between IHC4 score and response to neo-adjuvant chemotherapy in estrogen receptor-positive breast cancer.

Breast cancer research and treatment·2017

Same author

Clinical utility of the IHC4+C score in oestrogen receptor-positive early breast cancer: a prospective decision impact study.

British journal of cancer·2015

Same author

Identifying clinically relevant prognostic subgroups of postmenopausal women with node-positive hormone receptor-positive early-stage breast cancer treated with endocrine therapy: a combined analysis of ABCSG-8 and ATAC using the PAM50 risk of recurrence score and intrinsic subtype.

Annals of oncology : official journal of the European Society for Medical Oncology·2015

Same author

Residual proliferative cancer burden to predict long-term outcome following neoadjuvant chemotherapy.

Annals of oncology : official journal of the European Society for Medical Oncology·2014

Same author

The AURORA initiative for metastatic breast cancer.

British journal of cancer·2014

Area of Science:

Biomedical research
Cancer research
Translational medicine

Background:

New guidelines mandate ethical approval and patient consent for human tissue use in research.
Surplus tissues, like breast cancer biopsies, previously considered 'abandoned,' now face stricter regulations.
These changes impact the accessibility of valuable research materials.

Purpose of the Study:

To evaluate the impact of new human tissue guidelines on translational cancer research.
To argue that certain new constraints are unnecessary for patient protection.
To highlight the significance of these constraints in the context of emerging cancer research technologies.

Main Methods:

This article presents a critical analysis of current ethical guidelines and their implications.
It reviews the concept of 'abandoned' tissue and patient consent.
It discusses the potential impact on translational research using emerging technologies.

Main Results:

The new guidelines impose significant hurdles on researchers seeking to utilize human tissues.
These constraints may unnecessarily impede translational research, particularly in cancer.
Emerging technologies requiring substantial tissue samples are disproportionately affected.

Conclusions:

Some new ethical constraints on human tissue collection and use create unnecessary barriers to vital translational cancer research.
A re-evaluation of these guidelines is needed to balance ethical considerations with the advancement of clinical cancer research.
Facilitating access to surplus tissues is crucial for leveraging new technologies in cancer research.

Related Experiment Videos