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Acetyltransferases and tumour suppression.

A C Phillips¹, K H Vousden

¹Regulation of Cell Growth Laboratory, NCI-FCRDC, Frederick, Maryland 21702-1201, USA. phillips@ncifcrf.gov

Breast Cancer Research : BCR

|March 16, 2001

Summary

The acetyltransferase p300 (also known as EP300) may function as a tumor suppressor. Recent research found mutations in p300 in human cancers, suggesting its loss contributes to tumor development.

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Area of Science:

Molecular Biology
Oncology
Virology

Background:

The acetyltransferase p300 was initially identified in association with the adenoviral transforming protein E1A.
This association suggested a potential role for p300 in regulating cell proliferation.

Purpose of the Study:

To investigate the role of p300 in human tumors.
To provide direct evidence for p300's function in cancer development.

Main Methods:

Analysis of tumor samples and cell lines for mutations in the p300 gene.
Identification of truncating mutations and loss or mutation of the second allele.

Main Results:

Direct evidence supporting a tumor suppressor role for p300 in human cancers was established.
Truncating mutations and loss of heterozygosity in p300 were identified in tumor samples and cell lines.

Conclusions:

Loss or mutation of p300 is implicated in the development of a subset of human cancers.
p300 functions as a tumor suppressor, and its alteration contributes to oncogenesis.

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