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Regulation of interleukin-12 production by G-protein-coupled receptors
1Immune Cell Interaction Unit, Mucosal Immunity Section, Laboratory of Clinical Investigation, NIAID, NIH, Bldg. 10, 11-N-238, 10 Center Drive Bethesda, MD 20892, USA.
Microbes and Infection
|March 17, 2001
Abstract:
G-protein-coupled receptors have long been known to play a critical role in the recruitment and migration of leukocytes to areas of inflammation. This review will focus, however, on emerging data that G-protein-coupled receptors can modulate cytokine production by antigen-presenting cells including interleukin-12 and tumor necrosis factor-alpha and may therefore play a significant role in the regulation of innate and acquired immunity.