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Updated: Oct 9, 2026
Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants
Published on: January 26, 2019
Umbilical cord blood collection, banking, and transplantation: current status and issues relevant to perinatal
1Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA.
Insights
Cord blood stem cells offer treatments for human diseases. This review covers cord blood collection, banking, transplantation, and safety, examining clinical successes and controversies in 2000.
Area of Science:
- Hematology
- Regenerative Medicine
- Transplantation Immunology
Background:
- Umbilical cord blood stem cells have been used for treating human diseases since 1988.
- Increased media attention has led to greater interest from expectant parents in cord blood banking.
- The growing use of cord blood collection, banking, and transplantation has raised several controversies.
Purpose of the Study:
- To review the current status of cord blood collection indications and methods.
- To examine safety issues related to cryopreservation of cord blood units.
- To detail the clinical success of cord blood transplants from related and unrelated donors.
Main Methods:
- Literature review of cord blood collection, banking, and transplantation practices.
- Analysis of clinical outcomes from cord blood transplants.
- Examination of safety protocols for cord blood cryopreservation.
Main Results:
- Cord blood transplantation is an established therapy for various hematologic disorders.
- Successful transplants have been performed using both related and unrelated cord blood units.
- Established protocols exist for safe collection, processing, and cryopreservation of cord blood.
Conclusions:
- Cord blood transplantation is a viable and increasingly utilized therapeutic option.
- Ongoing research continues to expand the applications of cord blood stem cells.
- Addressing controversies and ensuring safety are crucial for the future of cord blood banking and transplantation.
Abstract:
As a result of recent media coverage of cord blood transplantation, expectant parents increasingly ask perinatal caregivers about the possibility of collecting and saving their newborn child's umbilical cord blood. Umbilical cord blood has been used as a source of hematopoeitic stem cells for the treatment of human disease since 1988. As a result of these initial successes, cord blood collection, banking, and transplantation has become increasingly used worldwide, giving rise to several controversies. We have reviewed the current status of the indications for cord blood collection, the methods of collection, and safety issues related to the cyropreservation of cord blood units. In addition, the clinical success of cord blood transplants from related and unrelated donors is detailed. We have examined the major issues concerning cord blood transplantation as it exists in the year 2000 to provide insight into this exciting area of clinical investigation.
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