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Changes in endogenous monoamines in aged rats.

J J Lee1, C K Chang, I M Liu

  • 1Department of General Surgery, Mackay Memorial Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan.

Clinical and Experimental Pharmacology & Physiology
|March 17, 2001
PubMed
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Ageing significantly alters brain and plasma monoamines, decreasing key neurotransmitters like dopamine and serotonin while increasing metabolites, suggesting widespread neurochemical changes with aging.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Aging Research

Background:

  • Age-related changes in endogenous neurotransmitters are documented but controversial.
  • Understanding these alterations is crucial for addressing age-associated neurological and physiological changes.

Purpose of the Study:

  • To investigate the impact of aging on monoamine levels in the cerebral cortex and plasma of Wistar rats.
  • To explore age-dependent modifications in neurotransmitter and metabolite concentrations.

Main Methods:

  • Used male Wistar rats at various ages (8 weeks, 6, 12, 24 months).
  • Analyzed monoamine levels in cerebral cortex and plasma samples.
  • Employed electrochemical detection for precise quantification.

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Main Results:

  • Observed significant decreases in L-dihydroxyphenylalanine (L-DOPA), dopamine (DA), serotonin (5-HT), and its metabolite 5-hydroxyindolacetic acid (5-HIAA) with aging.
  • Found reduced plasma noradrenaline and cerebral cortex adrenaline levels in aged rats.
  • Noted a decrease in 3,4-dihydroxyphenylacetic acid (DOPAC) but a marked increase in homovanillic acid (HVA) with aging.
  • Reported increased ratios of DOPAC/DA and 5-HIAA/5-HT, indicating altered monoamine oxidase activity.
  • Observed higher HVA/DOPAC ratios, suggesting changes in catechol-O-methyltransferase activity.

Conclusions:

  • Aging alters endogenous monoamine levels in both the brain and peripheral tissues.
  • These findings suggest significant neurochemical shifts associated with the aging process.
  • The study provides evidence for age-related dysregulation of monoamine metabolism.