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Magnetic coupling between water and creatine protons in human brain and skeletal muscle, as measured using inversion
M J Kruiskamp1, R A de Graaf, J van der Grond
1Department of Experimental in vivo NMR, Image Sciences Institute, University Medical Center Utrecht, Bolognalaan 50, NL-3584, CJ Utrecht, The Netherlands.
Abstract:
Using the inversion transfer technique, the possible magnetic coupling between water protons and the protons of low-molecular weight metabolites was investigated in human brain and skeletal muscle at 1.5 T. The localized (1)H-MR spectra were recorded at different times after selective inversion of the water resonance. Water inversion led to a significant transient reduction in the signal intensity of the methyl protons of creatine/phosphocreatine, in both tissues. This is indicative of magnetic coupling between the protons of water and those of creatine/phosphocreatine. Neither the choline and N-acetylaspartate protons in brain nor the protons of the trimethylammonium pool in skeletal muscle showed a significant magnetic coupling to mobile water.