Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of primary headaches.

L Edvinsson1

  • 1Department of Internal Medicine, Lund University Hospital, Lund S-221 85, Sweden. lars.edvinsson@med.lu.se

Current Pain and Headache Reports
|March 17, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Origin and Co-localization of nitric oxide synthase, CGRP, PACAP, and VIP in the cerebral circulation of the rat.

Microscopy research and technique·2001
Same author

4991W93 inhibits release of calcitonin gene-related peptide in the cat but only at doses with 5HT(1B/1D) receptor agonist activity?

Neuropharmacology·2001
Same author

Characterisation of the effects of a non-peptide CGRP receptor antagonist in SK-N-MC cells and isolated human cerebral arteries.

European journal of pharmacology·2001
Same author

Characterization of CGRP(1) receptors in the guinea pig basilar artery.

European journal of pharmacology·2001
Same author

A pathophysiological view of primary headaches.

Functional neurology·2001
Same author

Enhanced Ca2+-induced contractions and attenuated alpha-adrenoceptor responses in resistance arteries from rats with congestive heart failure.

European journal of heart failure·2001
Same journal

Analysis of the Effectiveness of Injection-Based Minimally Invasive Treatment for Piriformis Syndrome: Clinical Outcomes and Anatomical Correlates.

Current pain and headache reports·2026
Same journal

A Systematic Review and Meta-Analysis of Randomized Controlled Trials of Epidural Regenerative Medicine Therapies in Managing Spinal Pain.

Current pain and headache reports·2026
Same journal

Artificial Intelligence in Neuropathic Pain: From Mechanisms to Neuromodulation and Regenerative Strategies.

Current pain and headache reports·2026
Same journal

Proposed Conditions for Pain Reprocessing Therapy Readiness: Beyond Phenotyping Neuroplastic Pain.

Current pain and headache reports·2026
Same journal

Treatment of Headache in Children and Adolescents with POTS.

Current pain and headache reports·2026
Same journal

Pediatric Headache in the Age of Social Media: A Topical Review.

Current pain and headache reports·2026
See all related articles

Primary headaches involve neurotransmitter release from cranial nerves. Calcitonin gene-related peptide and vasoactive intestinal peptide are linked to head pain and facial symptoms, normalizing with sumatriptan treatment.

Area of Science:

  • Neuroscience
  • Neurology
  • Pharmacology

Background:

  • Cerebral circulation is innervated by sympathetic, parasympathetic, and sensory nerves.
  • These nerves store numerous neurotransmitters implicated in various physiological processes.
  • The role of these neurotransmitters in primary headaches requires further elucidation.

Purpose of the Study:

  • To investigate the involvement of specific neurotransmitters in the pathophysiology of primary headaches.
  • To evaluate the association between neuropeptide release and headache symptoms.
  • To assess the effect of sumatriptan treatment on neuropeptide levels and headache severity.

Main Methods:

  • Evaluation of neurotransmitter release in patients experiencing primary headaches.
  • Correlation of neuropeptide levels (calcitonin gene-related peptide, vasoactive intestinal peptide) with headache characteristics and facial symptoms.

Related Experiment Videos

  • Assessment of changes in neuropeptide release following sumatriptan treatment.

    • Main Results:

    • A significant association was found between head pain and the release of calcitonin gene-related peptide.
    • Vasoactive intestinal peptide release correlated with facial symptoms in cluster headache and chronic paroxysmal headache.
    • Sumatriptan treatment led to the subsidence of head pain and normalization of neuropeptide release.

    Conclusions:

    • Sensory and parasympathetic nerve mechanisms are involved in the pathophysiology of primary headaches.
    • Neuropeptides like CGRP and VIP play a crucial role in headache generation and associated symptoms.
    • Targeting these neuropeptide pathways, as with sumatriptan, offers a potential therapeutic strategy for primary headaches.