Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A cortical-hippocampal system for declarative memory.

H Eichenbaum1

  • 1Laboratory of Cognitive Neurobiology, Department of Psychology, Boston University, 64 Cummington Street, Boston, Massachusetts 02215, USA. hbe@bu.edu

Nature Reviews. Neuroscience
|March 17, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain rhythms: towards a coherent picture of ensemble development in learning.

Current biology : CB·2014
Same author

The hippocampal system and declarative memory in animals.

Journal of cognitive neuroscience·2013
Same author

Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology.

Genes, brain, and behavior·2010
Same author

An animal model of amnesia that uses Receiver Operating Characteristics (ROC) analysis to distinguish recollection from familiarity deficits in recognition memory.

Neuropsychologia·2009
Same author

Complementary roles of hippocampus and medial entorhinal cortex in episodic memory.

Neural plasticity·2008
Same author

Noradrenergic, but not cholinergic, deafferentation of prefrontal cortex impairs attentional set-shifting.

Neuroscience·2008
Same journal

Brain-spleen axis regulates learned fear.

Nature reviews. Neuroscience·2026
Same journal

Acetylcholine: a candidate substrate for hippocampal predictive learning?

Nature reviews. Neuroscience·2026
Same journal

Astrocytes viewed through the lens of their proteomes and subproteomes.

Nature reviews. Neuroscience·2026
Same journal

m<sup>6</sup>A in RNA: a key regulator of brain development, function and disease.

Nature reviews. Neuroscience·2026
Same journal

Non-invasive deep-brain neuromodulation by transcranial radio frequency stimulation.

Nature reviews. Neuroscience·2026
Same journal

Heading into the wild: setting the course to natural neuroscience.

Nature reviews. Neuroscience·2026
See all related articles

Neurobiology reveals how the neocortex, parahippocampal region, and hippocampus work together for declarative memory. This network enables the creation and recall of experiences and world knowledge.

Area of Science:

  • Neurobiology
  • Cognitive Neuroscience
  • Memory Research

Background:

  • Declarative memory, encompassing events and facts, is crucial for daily life.
  • Recent studies explore the neural underpinnings of memory formation and retrieval.
  • Understanding memory mechanisms is key to addressing memory disorders.

Purpose of the Study:

  • To elucidate the cognitive and neural coding mechanisms of declarative memory.
  • To describe the roles of the neocortex, parahippocampal region, and hippocampus in memory.
  • To explain how these brain regions interact to form and recall memories.

Main Methods:

  • Review of recent neurobiological studies on memory.
  • Analysis of neural circuitry involved in declarative memory.

Related Experiment Videos

  • Description of functional contributions of neocortical, parahippocampal, and hippocampal areas.

    • Main Results:

    • Declarative memory relies on bidirectional connections between neocortex, parahippocampal region, and hippocampus.
    • Neocortical areas process specific information, the parahippocampal region integrates it, and the hippocampus encodes sequences.
    • These regions collaboratively create networked representations of experiences and knowledge.

    Conclusions:

    • The integrated function of the neocortex, parahippocampal region, and hippocampus is essential for declarative memory.
    • This neural circuitry supports the dynamic creation and recreation of memories.
    • Further research can build upon these findings to understand memory disorders.