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Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
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Published on: November 18, 2013

Neurogenesis in the adult brain: death of a dogma

C G Gross1

  • 1Department of Psychology, Green Hall, Princeton University, Princeton, New Jersey 08544, USA. cggross@princeton.edu

Nature Reviews. Neuroscience
|March 17, 2001
PubMed

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...