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Circadian clockwork: two loops are better than one.

¹Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. mh105@cus.cam.ac.uk

Nature Reviews. Neuroscience

|March 17, 2001

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Recent research reveals a conserved molecular mechanism underlying mammalian circadian rhythms, offering insights into the genetic control of behavior. This discovery sheds light on our internal sense of time.

Area of Science:

Chronobiology
Molecular Biology
Behavioral Genetics

Background:

Mammalian circadian rhythms are fundamental biological processes.
Understanding the molecular basis of these rhythms is crucial for explaining behavior.

Purpose of the Study:

To describe recent evidence for a conserved molecular mechanism in eukaryotic circadian systems.
To discuss how these findings illuminate the sense of circadian time.

Main Methods:

Review of recent molecular and genetic studies on circadian clocks.
Comparative analysis of circadian systems across different eukaryotic organisms.

Main Results:

Evidence for a conserved double-loop, autoregulatory feedback mechanism in circadian systems.

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This mechanism provides a molecular framework for understanding circadian timekeeping.

Conclusions:

The conserved feedback loop is a key molecular determinant of circadian behavior.
This framework helps explain long-standing questions about the subliminal sense of circadian time.