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Updated: Jul 23, 2026

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
Published on: April 11, 2018
The gender gap in cystic fibrosis survival
1Case Western Reserve University School of Medicine, Biomedical Research Building, 8th Floor, 10900 Euclid Ave, Cleveland, OH 44106, USA. pbd@po.cwru.edu
Abstract:
Females with cystic fibrosis have significantly higher mortality than males from age 1 to age 20, resulting in an approximate four-year difference in median survival age. Survival is associated with a lack of colonization by pathogenic bacteria, as well as better pulmonary function, weight for height, and fitness. This statistically significant gender gap has been observed for decades and, therefore, is not likely to be the result of differential response to one of the newer treatments for cystic fibrosis.
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