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Updated: Jun 20, 2026

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
Published on: March 5, 2017
Rab proteins as membrane organizers
1Max-Planck-Institute of Molecular Cell Biology and Genetics, c/o EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Zerial@EMBL-Heidelberg.de
Abstract:
Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial distribution and communicate through an elaborate system of vesiculo-tubular transport. Rab proteins and their effectors coordinate consecutive stages of transport, such as vesicle formation, vesicle and organelle motility, and tethering of vesicles to their target compartment. These molecules are highly compartmentalized in organelle membranes, making them excellent candidates for determining transport specificity and organelle identity.
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