Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.3K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.3K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.4K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.4K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

7.9K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.9K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

2.4K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.4K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.8K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.8K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

14.9K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
14.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions.

Oncogene·2025
Same author

Correction: Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions.

Oncogene·2024
Same author

Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans.

Cell death & disease·2022
Same author

Modeling and predicting optimal treatment scheduling between the antiangiogenic drug sunitinib and irinotecan in preclinical settings.

CPT: pharmacometrics & systems pharmacology·2016
Same author

The EGFR-HER2 module: a stem cell approach to understanding a prime target and driver of solid tumors.

Oncogene·2015
Same author

An antibody to amphiregulin, an abundant growth factor in patients' fluids, inhibits ovarian tumors.

Oncogene·2015
Same journal

Human aminoacyl-tRNA synthetases as integrators of translation and cell signalling networks.

Nature reviews. Molecular cell biology·2026
Same journal

How proteins fold.

Nature reviews. Molecular cell biology·2026
Same journal

Single-cell evidence for PANoptosome complexes.

Nature reviews. Molecular cell biology·2026
Same journal

Reply to 'Single-cell evidence for PANoptosome complexes'.

Nature reviews. Molecular cell biology·2026
Same journal

Plucking cellular ribosomes with Ribo-Tweezer.

Nature reviews. Molecular cell biology·2026
Same journal

COPII meets autophagy at the ER membrane.

Nature reviews. Molecular cell biology·2026
See all related articles

Related Experiment Video

Updated: Nov 7, 2025

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

8.9K

Untangling the ErbB signalling network.

Y Yarden1, M X Sliwkowski

  • 1Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel. yosef.yarden@weizmann.ac.il

Nature Reviews. Molecular Cell Biology
|March 17, 2001
PubMed
Summary
This summary is machine-generated.

Understanding the ErbB receptor signaling network provides insights into cancer development and targeted therapies. This knowledge has led to treatments like trastuzumab for breast cancer, demonstrating the clinical benefit of molecular research.

More Related Videos

Dissecting Multi-protein Signaling Complexes by Bimolecular Complementation Affinity Purification BiCAP
06:45

Dissecting Multi-protein Signaling Complexes by Bimolecular Complementation Affinity Purification BiCAP

Published on: June 15, 2018

7.7K
Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
08:40

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline

Published on: November 29, 2016

10.5K

Related Experiment Videos

Last Updated: Nov 7, 2025

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

8.9K
Dissecting Multi-protein Signaling Complexes by Bimolecular Complementation Affinity Purification BiCAP
06:45

Dissecting Multi-protein Signaling Complexes by Bimolecular Complementation Affinity Purification BiCAP

Published on: June 15, 2018

7.7K
Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
08:40

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline

Published on: November 29, 2016

10.5K

Area of Science:

  • Molecular biology and cell signaling
  • Oncology and cancer therapeutics
  • Translational medicine

Background:

  • Epidermal growth factor (EGF) and related ligands activate the ErbB receptor family.
  • ErbB signaling pathways regulate crucial cellular processes including division, motility, and adhesion.
  • Dysregulation of these pathways is frequently observed in various cancers.

Purpose of the Study:

  • To explore the implications of the ErbB signaling network in cancer biology.
  • To highlight the translation of basic scientific understanding into clinical applications.
  • To examine the success of targeted therapies based on ErbB pathway knowledge.

Main Methods:

  • Review of molecular mechanisms underlying ErbB receptor activation and downstream signaling.
  • Analysis of clinical data and therapeutic strategies targeting ErbB receptors.
  • Case study of trastuzumab (Herceptin) in breast cancer treatment.

Main Results:

  • ErbB pathway dysregulation is a hallmark of cancer, driving uncontrolled cell proliferation and metastasis.
  • Targeted therapies, such as trastuzumab against ErbB2, have shown significant clinical efficacy.
  • Ongoing development of small-molecule inhibitors and monoclonal antibodies for ErbB1 and other family members.

Conclusions:

  • The ErbB signaling network serves as a prime example of how fundamental biological research can yield direct clinical benefits.
  • Targeted inhibition of specific ErbB receptors represents a successful strategy in cancer therapy.
  • Continued molecular investigation of signaling pathways is crucial for advancing cancer treatment.