Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hypertensive disorders in pregnancy].

G Wolf1, U Wenzel, R A Stahl

  • 1Medizinische Klinik, Abteilung Nephrologie und Osteologie, Universitätsklinikum Hamburg-Eppendorf. Wolf@uke.uni-hamburg.de

Medizinische Klinik (Munich, Germany : 1983)
|March 20, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Umbilical vein blood volume flow rate and umbilical artery pulsatility as 'venous-arterial index' in the prediction of neonatal compromise.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2002
Same author

[Uteroplacental and fetal arterial Ultrasound Doppler Flow Velocity measurements in unselected pregnancies as a screening test at 32 to 34 gestational weeks].

Zeitschrift fur Geburtshilfe und Neonatologie·2002
Same author

BK(Ca) channel activation by membrane-associated cGMP kinase may contribute to uterine quiescence in pregnancy.

American journal of physiology. Cell physiology·2000
Same author

Pregnancy switches adrenergic signal transduction in rat and human uterine myocytes as probed by BKCa channel activity.

The Journal of physiology·2000
Same author

[Recent developments in obstetric regional anesthesia. A review of experiences at the Eppendorf University Hospital].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·1999
Same author

Blood flow through the ductus venosus in singleton and multifetal pregnancies and in fetuses with intrauterine growth retardation.

American journal of obstetrics and gynecology·1998

Hypertensive disorders in pregnancy, including preeclampsia/eclampsia, pose risks to mothers and infants. Early identification and management of hypertension are crucial for better outcomes.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Cardiovascular Physiology in Pregnancy

Background:

  • Hypertensive disorders in pregnancy range from transient hypertension to severe preeclampsia/eclampsia, contributing significantly to maternal and fetal morbidity.
  • Accurate diagnosis necessitates understanding normal pregnancy-related physiological adaptations.
  • These conditions encompass a spectrum of disorders, highlighting the complexity of managing hypertension during gestation.

Purpose of the Study:

  • To elucidate the pathophysiology of preeclampsia/eclampsia, focusing on trophoblast dysfunction and maternal immunotolerance.
  • To outline current therapeutic strategies and management guidelines for hypertensive disorders in pregnancy.
  • To emphasize the importance of risk identification, monitoring, and interdisciplinary care for affected patients.

Related Experiment Videos

Main Methods:

  • Investigated the role of disturbed trophoblast growth and altered maternal immunotolerance in preeclampsia/eclampsia pathogenesis.
  • Analyzed changes in endothelial cell function, uteroplacental perfusion, and the renin-angiotensin system.
  • Reviewed pharmacological interventions, diagnostic criteria, and management protocols for hypertensive diseases in pregnancy.

Main Results:

  • Preeclampsia/eclampsia results from impaired trophoblast growth, leading to endothelial dysfunction, reduced perfusion, and an imbalance favoring vasoconstriction.
  • Hypertension in pregnancy is characterized by altered renin-angiotensin system activity and increased angiotensin II-mediated vasoconstriction.
  • Manifestations include disturbed microcirculation in target organs (brain, liver, kidney) and potential HELLP syndrome development.

Conclusions:

  • Effective management involves identifying at-risk patients, continuous monitoring, and treating hypertension with agents like alpha-methyldopa or dihydralazine.
  • ACE-inhibitors and angiotensin II receptor antagonists are contraindicated, while diuretics are relatively contraindicated.
  • Delivery remains the definitive treatment; management requires an interdisciplinary approach in tertiary centers, with potential benefits from early glucocorticoid therapy for HELLP syndrome.