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[Effect of substance P on ethanol consumption in subchronically alcoholized rats in the limited scheduled access
E P Bychkov1, A A Lebedev, S A Dambinova
1Institute of the Human Brain, Russian Academy of Sciences, Institute for Experimental Medicine, Russian Academy of Medical Sciences, St.-Petersburg.
Abstract:
The effect of substance P on alcohol intake was studied in rats using a limited scheduled access paradigm. Ascending doses of substance P (100 and 200 micrograms/kg) were administered intraperitoneally to rats approximately 30 minute prior to their 1-hour-per-day access to alcohol. Each dose was administered for 3 successive days, and the effect of substance P was compared to that of saline solution control. Substance P at the dose of 100 micrograms/kg had no effect on alcohol consumption but significantly decreased the alcohol intake at the dose of 200 micrograms/kg. Thus, substance P reduces the alcohol motivation of rats in a limited scheduled access paradigm.
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