[Modelling cerebrovascular circulation from the viewpoint of autoregulation mechanisms]

The rationale for cerebral blood flow modelling is to extrapolate the possible effects of the pharmacological agents and significance of different pathologic states. Most authors present linear, statistical models. Such modelling does not take into consideration many important factors. Autoregulation of cerebral circulation is the most important one. It maintains cerebral blood flow on a constant level despite significant changes of systemic pressure. Influence of autoregulation is necessary for evaluation of the different anatomical configurations of the main supplying arteries and the cerebral arterial circle of Willis. This paper presents original, non-linear and dynamic model of the cerebral circulation with factor of autoregulation. Comparison of the data from the modelling and from the clinical observations shows high correlation.