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Mobile elements and the human genome
1Department of Genetics, 475 Clinical Research Building, 415 Curie Boulevard, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Nature Reviews. Genetics
|March 20, 2001
Abstract:
Genomic DNA is often thought of as the stable template of heredity, largely dormant and unchanging, apart from perhaps the occasional point mutation. But it has become increasingly clear that DNA is dynamic rather than static, being subjected to rearrangements, insertions and deletions. Much of this plasticity can be attributed to transposable elements and their genomic relatives.