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Arterial compliance in patients with cirrhosis: stroke volume-pulse pressure ratio as simplified index

J H Henriksen1, S Fuglsang, F Bendtsen

  • 1Department of Clinical Physiology, Hvidovre Hospital, University of Copenhagen, DK-2650 Hvidovre, Denmark. jens.h.henriksen@hh.hosp.dk

American Journal of Physiology. Gastrointestinal and Liver Physiology
|March 20, 2001
PubMed

Insights

Arterial compliance is elevated in patients with cirrhosis. A simplified stroke volume-pulse pressure index (SV/PP) effectively reflects these arterial abnormalities in cirrhotic individuals.

Area of Science:

  • Cardiovascular Physiology
  • Hepatology
  • Vascular Medicine

Background:

  • Cirrhosis can significantly impact arterial function.
  • Understanding hemodynamic changes is crucial for managing cirrhotic patients.

Purpose of the Study:

  • To determine arterial tree compliance (C(1)) in cirrhosis.
  • To correlate C(1) with systemic and splanchnic hemodynamics.
  • To assess the utility of the stroke volume-pulse pressure index (SV/PP) as a marker.

Main Methods:

  • Measured arterial compliance (C(1)) and SV/PP in cirrhotic patients and controls.
  • Analyzed relationships between C(1), SV/PP, and clinical/hemodynamic variables.
  • Utilized univariate and multiple-regression analyses.

Main Results:

  • Arterial compliance (C(1)) and SV/PP were significantly higher in cirrhotic patients.
  • Strong correlations were observed between C(1) and SV/PP in both groups.
  • Multiple regression identified sex, age, blood pressure, vascular resistance, and biochemical variables as predictors of SV/PP.

Conclusions:

  • Arterial compliance is elevated in patients with cirrhosis.
  • The SV/PP index serves as a reliable indicator of altered arterial compliance in cirrhosis.

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