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Updated: Jul 25, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
Trauma critical care
1Departments of Surgery and Medicine, and Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, and University of Washington, Seattle, Washington 98104, USA. larrygen@u.washington.edu
Surgical care for critically injured patients now involves intensive care unit (ICU) management of hypothermia, acidosis, and coagulopathy. Prompt correction of this triad is vital for patient survival and surgical completion.
Area of Science:
- Trauma Surgery
- Critical Care Medicine
- Surgical Physiology
Background:
- Modern surgical approaches for severely injured patients have evolved.
- Many patients now require intensive care unit (ICU) management for conditions previously addressed in the operating room.
- Delayed definitive surgical treatment can occur due to physiological deterioration.
Purpose of the Study:
- To highlight the critical importance of managing the triad of hypothermia, acidosis, and coagulopathy in critically injured patients.
- To emphasize the role of the ICU in correcting these physiological derangements.
- To underscore the necessity of addressing abdominal compartment syndrome.
Main Methods:
- This abstract discusses a shift in clinical practice regarding the management of severely injured patients.
- It focuses on the physiological challenges encountered in the intensive care unit.
- The abstract emphasizes the critical factors requiring correction.
Main Results:
- The triad of hypothermia, acidosis, and coagulopathy is a significant challenge in trauma care.
- Abdominal compartment syndrome is a frequent complication requiring attention.
- Failure to interrupt this triad leads to mortality during resuscitation.
Conclusions:
- Correction of hypothermia, acidosis, and coagulopathy in the ICU is essential for critically injured patients.
- Prompt intervention allows for necessary surgical procedures to be completed.
- Interrupting this lethal triad is crucial for preventing death during resuscitation efforts.
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