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Related Experiment Videos

Cutaneous squamous cell carcinoma and p53 codon 72 polymorphism: a need for screening?

M T Bastiaens1, L Struyk, S P Tjong-A-Hung

  • 1Department of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands.

Molecular Carcinogenesis
|March 20, 2001
PubMed
Summary

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The p53 codon 72 arginine genotype does not increase the risk for developing cutaneous squamous cell carcinoma. This finding suggests that genetic screening for this polymorphism is not necessary for cancer prevention strategies.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • The association between human papillomavirus (HPV) and cancers like cervical cancer is established.
  • The role of p53 gene codon 72 polymorphism, specifically the arginine form, in the risk of cutaneous squamous cell carcinoma (cSCC) remains unclear.
  • It is uncertain whether the arginine genotype is a risk factor or a tumor marker for cSCC.

Purpose of the Study:

  • To investigate the risk of developing cSCC in individuals with the p53 codon 72 arginine genotype.
  • To determine if genetic screening for the p53 codon 72 arginine genotype is warranted for cSCC prevention.

Main Methods:

  • A case-control study was conducted.
  • Genotyping of p53 codon 72 was performed using polymerase chain reaction (PCR) on DNA from peripheral blood lymphocytes.

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  • The study included patients with cSCC, basal cell carcinoma, malignant melanoma, and healthy controls.
  • Epidermodyplasia verruciformis human papillomavirus (EV-HPV) DNA was analyzed in a subgroup.

    • Main Results:

    • The frequency distribution of p53 codon 72 genotypes (arginine homozygote, heterozygote, proline homozygote) was similar between cSCC cases and controls.
    • No statistically significant differences were observed in genotype distributions among cSCC, basal cell carcinoma, malignant melanoma, and control groups.
    • Similar findings were noted in subgroups with and without EV-HPV DNA.

    Conclusions:

    • The p53 codon 72 arginine homozygosity is not a significant risk factor for cutaneous squamous cell carcinoma.
    • Routine screening for this specific p53 genotype is not indicated for cSCC prevention.