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[Comparative study of DNA-specific dyes of the indole and benzimidazole derivates]
V S Sibirtsev1, A V Garabadzhiu, S D Ivanov
1Central Research Institute of Roentgenology and Radiolology, Russian Ministry of Public Health, Leningradskaya ul., 70/4, Pesochny-2, St. Petersburg, 189646 Russia.
Bioorganicheskaia Khimiia
|March 21, 2001
Abstract:
Various models of complex formation of low-molecular ligands with DNA are considered. Using the Scatchard model, parameters of binding of fluorescent monophenylindole, monophenylbenzimidazole, and bisbenzimidazole dyes with calf thymus DNA were evaluated. By means of graphic (nonparametric) and correlation analysis, various spectral and complexation properties of these dyes in the presence of DNA are compared.