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[Gene therapy in cancer].

E Hovig1, O Myklebost, S Aamdal

  • 1Det Norske Radiumhospital 0310 Oslo. ehovig@radium.uio.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|March 21, 2001
PubMed
Summary

Gene therapy shows promise for cancer treatment, with many clinical trials underway. While early results are encouraging, larger studies are needed to confirm effectiveness and clinical importance.

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Nature communications·2018

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Context:

  • Cancer pathogenesis understanding has grown significantly.
  • New treatments are emerging based on this knowledge.
  • Gene therapy is a key area of research.

Purpose:

  • To review the literature on gene therapy for cancer.
  • To present the status of approved gene therapy protocols in Norway.
  • To assess the current landscape of cancer gene therapy.

Summary:

  • Over 70% of clinical gene therapy studies target cancer, employing various strategies like targeting oncogenes or using suicide gene therapy.
  • Early-phase trials (I and II) focus on safety and toxicity, with some showing partial or complete tumor remission.
  • TP53 gene therapy trials have demonstrated effects on tumor size in up to 50% of patients.

Impact:

  • Gene therapy offers promising avenues for cancer treatment.
  • Further large-scale, controlled clinical trials are essential to validate these findings.
  • Norway has approved its first gene therapy protocols for cancer treatment.

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