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[Gene therapy in cancer].

E Hovig1, O Myklebost, S Aamdal

  • 1Det Norske Radiumhospital 0310 Oslo. ehovig@radium.uio.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|March 21, 2001
PubMed
Summary
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Gene therapy shows promise for cancer treatment, with many clinical trials underway. While early results are encouraging, larger studies are needed to confirm effectiveness and clinical importance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Context:

  • Cancer pathogenesis understanding has grown significantly.
  • New treatments are emerging based on this knowledge.
  • Gene therapy is a key area of research.

Purpose:

  • To review the literature on gene therapy for cancer.
  • To present the status of approved gene therapy protocols in Norway.
  • To assess the current landscape of cancer gene therapy.

Summary:

  • Over 70% of clinical gene therapy studies target cancer, employing various strategies like targeting oncogenes or using suicide gene therapy.
  • Early-phase trials (I and II) focus on safety and toxicity, with some showing partial or complete tumor remission.
  • TP53 gene therapy trials have demonstrated effects on tumor size in up to 50% of patients.

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Impact:

  • Gene therapy offers promising avenues for cancer treatment.
  • Further large-scale, controlled clinical trials are essential to validate these findings.
  • Norway has approved its first gene therapy protocols for cancer treatment.