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[Leptospirosis after a staff outing].

C Stephan1, K P Hunfeld, A Schönberg

  • 1Schwerpunkt Infektiologie, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main. C.Stephan@em.uni-frankfurt.de

Deutsche Medizinische Wochenschrift (1946)
|March 21, 2001
PubMed
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Three colleagues contracted leptospirosis after a rafting accident. Early clinical diagnosis and treatment with antibiotics led to rapid recovery, highlighting the importance of recognizing non-specific symptoms of this bacterial infection.

Area of Science:

  • Infectious Diseases
  • Bacteriology
  • Clinical Medicine

Background:

  • Leptospirosis is a zoonotic bacterial infection caused by pathogenic spirochetes of the genus Leptospira.
  • Anicteric leptospirosis, particularly non-Weil's disease, can present with non-specific symptoms, complicating diagnosis.
  • Exposure to contaminated water is a primary risk factor for acquiring leptospirosis.

Observation:

  • Three male colleagues presented with acute symptoms including high fever, chills, headache, meningismus, facial paralysis, mild hepatitis, and renal involvement following a recreational river rafting incident.
  • Laboratory investigations revealed elevated inflammatory markers, signs of hepatitis and renal dysfunction, and the presence of leptospirosis antibodies.
  • Microscopic agglutination tests (MAT) confirmed antibodies against Leptospira interrogans serovar Bataviae in two of the three patients.

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Findings:

  • Clinical presentation and serological tests confirmed leptospirosis in all three patients, with laboratory confirmation in two.
  • Treatment with doxycycline or ceftriaxone resulted in rapid and complete resolution of symptoms.
  • The cases exhibited significant neurotropism, suggesting this may be a characteristic feature of Leptospira serovar Bataviae infections.

Implications:

  • The study underscores the critical role of clinical diagnosis in leptospirosis, especially when laboratory tests are inconclusive or negative.
  • Prompt antibiotic treatment is effective in managing leptospirosis, leading to favorable patient outcomes.
  • The observed neurotropism associated with Leptospira serovar Bataviae warrants further investigation for potential diagnostic and prognostic significance.