Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Therapeutic target discovery using Caenorhabditis elegans.

E M Link1, G Hardiman, A E Sluder

  • 1Cambria Biosciences, Bedford, MA 01730, USA.

Pharmacogenomics
|March 21, 2001
PubMed
Summary

The nematode Caenorhabditis elegans offers a powerful model for identifying and validating therapeutic targets. Its genetic tractability and completed genome accelerate drug discovery by elucidating gene functions and pathways.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A case study approach to high-containment laboratory workflows promoting sustainability, networking and innovation.

Revue scientifique et technique (International Office of Epizootics)·2022
Same author

Novel multiparameter correlates of Coxiella burnetii infection and vaccination identified by longitudinal deep immune profiling.

Scientific reports·2020
Same author

Building Patient-Physician Trust: A Medical Student Perspective.

Academic medicine : journal of the Association of American Medical Colleges·2020
Same author

Establishing the European Norm for the health-related quality of life domains of the computer-adaptive test EORTC CAT Core.

European journal of cancer (Oxford, England : 1990)·2018
Same author

General population normative data for the EORTC QLQ-C30 health-related quality of life questionnaire based on 15,386 persons across 13 European countries, Canada and the Unites States.

European journal of cancer (Oxford, England : 1990)·2018
Same author

Large Draining Focal Fibrous Hyperplasia Secondary to Periapical Granuloma.

Case reports in dentistry·2018

Area of Science:

  • Genomics
  • Pharmacology
  • Developmental Biology

Background:

  • Therapeutic development requires identifying genes amenable to pharmacological intervention.
  • Understanding gene function and biochemical pathways is crucial for validating drug targets.

Purpose of the Study:

  • To highlight the utility of Caenorhabditis elegans as a model organism for drug discovery.
  • To demonstrate how C. elegans can aid in identifying and validating therapeutic targets.

Main Methods:

  • Leveraging established genetic and experimental manipulation techniques in C. elegans.
  • Utilizing the completed genome sequence of C. elegans for molecular genetic experiments.
  • Adapting C. elegans for high-throughput chemical screening.

Related Experiment Videos

Main Results:

  • C. elegans facilitates the elucidation of gene functions and biochemical pathways relevant to human diseases.
  • Molecular genetic studies in C. elegans contribute to the validation of potential therapeutic targets.
  • High-throughput screening in C. elegans aids in identifying lead compounds for drug development.

Conclusions:

  • Caenorhabditis elegans is an advantageous model organism for advancing therapeutic target identification and validation.
  • The genetic and genomic resources of C. elegans significantly enhance drug discovery pipelines.
  • C. elegans research provides a foundation for developing novel pharmacological interventions.