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Related Experiment Videos

Neuroimaging in bipolar disorder.

S M Strakowski1, M P DelBello, C Adler

  • 1Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559, USA. strakosm@email.uc.edu

Bipolar Disorders
|March 21, 2001
PubMed
Summary

Neuroimaging studies suggest abnormalities in frontal-subcortical brain circuits in bipolar disorder. Further research is needed to fully understand the neurophysiology of this illness.

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Area of Science:

  • Neuroscience
  • Psychiatry

Background:

  • Bipolar disorder is a complex mood disorder with unclear neurophysiological underpinnings.
  • Neuroimaging offers a window into brain structure and function in psychiatric conditions.

Purpose of the Study:

  • To review neuroimaging literature on bipolar disorder.
  • To evaluate contributions to understanding the illness's neurophysiology.

Main Methods:

  • Systematic review of neuroimaging studies.
  • Searched PubMed (NIMH) for studies comparing bipolar disorder patients to healthy controls.
  • Included studies with at least five participants.

Main Results:

  • Mixed results for ventricular size.
  • Evidence of subcortical (striatum, amygdala) and prefrontal cortex structural abnormalities.

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  • Abnormalities in choline and phospholipid metabolism suggested by spectroscopy.
  • Functional imaging shows altered glucose metabolism and blood flow, particularly in the prefrontal cortex during depression, but lacks specificity.

    • Conclusions:

    • Current neuroimaging literature on bipolar disorder is limited.
    • Abnormalities in frontal-subcortical circuits are likely.
    • Further targeted neuroimaging studies are crucial for advancing understanding.