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Gynecologic malignancies accompanied by benign hormone-dependent diseases
M Koshiyama1, Y Morita, H Fujii
1Department of Obstetrics and Gynecology, Tenri Hospital, Nara, Japan.
Menopause (New York, N.Y.)
|March 21, 2001
Summary
Postmenopausal women with endometrial carcinoma show a higher prevalence of uterine fibroids (myoma uteri) and adenomyosis. These benign gynecologic conditions appear more common in those diagnosed with this hormone-dependent malignancy.
Area of Science:
- Gynecologic Oncology
- Reproductive Endocrinology
Background:
- Benign gynecologic diseases like myoma uteri and adenomyosis are common in postmenopausal women.
- Hormone-dependent malignancies, such as endometrial carcinoma, also affect this demographic.
Purpose of the Study:
- To investigate the correlation between benign gynecologic diseases (myoma uteri, adenomyosis uteri) and endometrial carcinoma in postmenopausal women.
Main Methods:
- Retrospective analysis of 136 endometrial carcinoma cases.
- Comparison with 222 control cases of uterine prolapse in postmenopausal women.
Main Results:
- Prevalence of myoma uteri and adenomyosis uteri in controls: 21.6% and 9.9% respectively.
- Postmenopausal women with endometrial carcinoma exhibited a 1.5- to 2-fold higher prevalence of myoma uteri and adenomyosis uteri compared to controls.
Conclusions:
- A significantly higher prevalence of myoma uteri and adenomyosis uteri was observed in postmenopausal patients diagnosed with endometrial carcinoma.
- These findings suggest a potential link between these benign gynecologic conditions and endometrial cancer risk in postmenopausal women.