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Telomerase and cancer.

J W Shay1, Y Zou, E Hiyama

  • 1The University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA. jerry.shay@utsouthwestern.edu

Human Molecular Genetics
|March 21, 2001
PubMed
Summary

Telomerase, a ribonucleoprotein complex, maintains telomere length in cancer cells. Recent advances explore its role in diagnostics and anti-cancer therapies.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Telomerase is a ribonucleoprotein (RNP) complex essential for maintaining telomere length.
  • Telomere length stability is crucial and often dysregulated in cancer cells.
  • Recent progress has focused on identifying telomerase components and associated proteins.

Purpose of the Study:

  • To review recent advances in understanding telomerase holoenzyme complex.
  • To elucidate mechanisms of telomere length regulation.
  • To cover telomerase applications in cancer diagnostics and therapeutics.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of studies on telomerase components and telomere-associated proteins.
  • Synthesis of information on diagnostic and therapeutic strategies involving telomerase.

Main Results:

  • Significant progress in identifying telomerase holoenzyme components.
  • Elucidation of mechanisms regulating telomere length.
  • Emerging applications of telomerase in cancer diagnostics.
  • Development of anti-telomerase cancer therapeutic approaches.

Conclusions:

  • Telomerase plays a critical role in cancer cell proliferation.
  • Understanding telomerase offers potential for novel cancer diagnostics.
  • Anti-telomerase strategies represent a promising avenue for cancer therapy.

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