Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The ABC of APC.

N S Fearnhead1, M P Britton, W F Bodmer

  • 1Cancer and Immunogenetics Laboratory, Imperial Cancer Research Fund, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.

Human Molecular Genetics
|March 21, 2001
PubMed
Summary

Familial adenomatous polyposis (FAP) is an inherited condition causing colon polyps and cancer due to mutations in the adenomatous polyposis coli (APC) gene. This review explores how APC gene mutations impact protein function and contribute to colorectal cancer development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defining Standard Data Reporting in Pelvic Exenterations for Non-Rectal Cancers: A Systematic Review of Current Data Reporting.

Cancers·2025
Same author

Similar success rate in proximal and distal colonic stent placement: a retrospective multi-center study.

Scandinavian journal of gastroenterology·2023
Same author

Comment on Ecker et al., Techniques in Coloproctology 27:339-342, 2023.

Techniques in coloproctology·2023
Same author

Severity of Dementia and Survival in Patients Diagnosed with Colorectal Cancer: A National Cohort Study in England and Wales.

Clinical oncology (Royal College of Radiologists (Great Britain))·2022
Same author

Operative blood loss adversely affects short and long-term outcomes after colorectal cancer surgery: results of a systematic review and meta-analysis.

Techniques in coloproctology·2022
Same author

Some Thoughts on AI Stimulated by Michael Wooldridge's Book "The Road to Conscious Machines. The Story of AI".

Kunstliche intelligenz·2022

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Familial adenomatous polyposis (FAP) is an autosomal dominant disorder.
  • FAP is characterized by numerous adenomatous polyps in the colon and rectum.
  • Untreated FAP inevitably leads to colorectal cancer.

Purpose of the Study:

  • To review the current understanding of APC gene mutations in FAP.
  • To explore the functional consequences of APC mutations at the protein level.
  • To elucidate the role of APC in colorectal tumorigenesis.

Main Methods:

  • Literature review of studies on FAP and APC gene.
  • Analysis of the molecular mechanisms linking APC mutations to colorectal cancer.
  • Examination of APC protein functions in cellular pathways.

Main Results:

  • Germline mutations in the APC gene cause FAP.
  • Somatic APC mutations are early events in most colorectal tumors.
  • APC protein is involved in Wnt signaling, cell adhesion, cytoskeleton stability, cell cycle, and apoptosis.

Conclusions:

  • APC gene mutations are central to FAP pathogenesis.
  • Altered APC protein function due to mutations drives colorectal carcinogenesis.
  • Understanding APC's multifaceted roles is key to comprehending colorectal cancer development.

Related Experiment Videos