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Updated: Aug 19, 2026

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
Published on: November 9, 2017
Fluid-phase uptake and transit in axenic Dictyostelium cells
1Abt. Zellbiologie, Universität GhK, Heinrich-Plett-Str. 40, D-34132, Kassel, Germany. maniak@uni-kassel.de
Abstract:
The main route for fluid-phase uptake in Dictyostelium is macropinocytosis, a process powered by the actin cytoskeleton. Nutrients within the endocytosed fluid are digested and resorbed, disposal of remnants follows by exocytosis. Along the endocytic pathway, membrane fusion and fission events take place at multiple steps. The regulator and effector molecules involved in uptake and transit are largely conserved between higher and lower eukaryotes. This feature, together with its accessibility by molecular genetics, recommend Dictyostelium as a valuable model system for mammalian cells.
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