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Fibrinogen is an efficient antioxidant.

R M. Olinescu1, F A. Kummerow

  • 1The Burnsides Research Laboratory, 61801, Urbana, IL, USA

The Journal of Nutritional Biochemistry
|March 21, 2001
PubMed
Summary

Fibrinogen, known as a vascular disease risk factor, demonstrates antioxidant properties. This study shows fibrinogen inhibits oxidative stress in vitro, acting as a key component of the body's antioxidant defense.

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Area of Science:

  • Biochemistry
  • Vascular Biology
  • Oxidative Stress Research

Background:

  • Fibrinogen is recognized as a risk factor for vascular diseases.
  • Fibrinogen is an acute phase protein, alongside albumin, ceruloplasmin, and transferrin.
  • Albumin, ceruloplasmin, and transferrin are established natural antioxidants.

Purpose of the Study:

  • To investigate the potential antioxidant activity of fibrinogen in an in vitro system.
  • To determine if fibrinogen can mitigate oxidative damage induced by various oxygen-generating systems.

Main Methods:

  • Utilized three distinct in vitro oxygen-generating systems: pyrogallol auto-oxidation, xanthine oxidase-catalyzed reactions with ferricytochrome c reduction, and chemiluminescence assays.
  • Assessed fibrinogen's inhibitory effects on superoxide generation, ferrous ion oxidation, hydroxyl radical-dependent degradation of deoxyribose, LDL oxidation, and hydrogen peroxide oxidation.

Main Results:

  • Fibrinogen exhibited dose-dependent inhibition of superoxide generation in both pyrogallol and xanthine-xanthine oxidase reactions.
  • Fibrinogen effectively inhibited ferrous ion oxidation, hydroxyl radical-dependent deoxyribose degradation, and LDL oxidation.
  • Fibrinogen suppressed chemiluminescence produced by polymorphonuclear leukocytes, indicating reduced oxidative activity.

Conclusions:

  • Fibrinogen possesses significant in vitro antioxidant capabilities.
  • Fibrinogen, along with albumin, ceruloplasmin, and transferrin, contributes to the supplementary antioxidant defense system against oxidative stress, particularly during inflammatory conditions.

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