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Updated: Aug 6, 2026

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
Published on: February 1, 2016
In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography
E O. Aboagye1, P M. Price, T Jones
1PET Oncology Group Department of Cancer Medicine, Imperial College School of Medicine MRC Cyclotron Unit, Hammersmith Hospital Du Cane Road, W12 0NN, London, UK
Abstract:
Positron-emission tomography (PET) is a sensitive technique that can be used to measure drug pharmacokinetics and pharmacodynamics non-invasively in target tissues of patients. Here we focus on the application of this technology to address some of the bottlenecks in drug development, including: elucidation of pathophysiology, evaluation of pharmacokinetics, proof of principle of mechanism, and assessment of efficacy and/or response to therapy.
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