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Issues in implementing prenatal screening for cystic fibrosis: results of a working conference

J E Haddow1, L A Bradley, G E Palomaki

  • 1Foundation for Blood Research, Scarborough, Maine 04070-0190, USA. jbeaudoi@fbr.org

Genetics in Medicine : Official Journal of the American College of Medical Genetics
|March 22, 2001
PubMed

Insights

Prenatal screening for cystic fibrosis (CF) is ready for routine practice. Cost-effective methods and existing educational materials support its implementation, with ethical considerations being manageable.

Area of Science:

  • Medical Genetics
  • Public Health
  • Reproductive Medicine

Background:

  • Cystic fibrosis (CF) is a genetic disorder requiring effective screening strategies.
  • Integrating genetic screening into prenatal care necessitates careful planning and expert consensus.

Purpose of the Study:

  • To convene experts and evaluate the feasibility of introducing cystic fibrosis screening into routine prenatal care.
  • To identify requirements and best practices for implementing prenatal CF screening.

Main Methods:

  • A conference involving multidisciplinary experts.
  • Presentation and discussion of systematic reviews and trial data.
  • Identification and analysis of key implementation issues.

Main Results:

  • Prenatal cystic fibrosis screening meets established criteria for introduction into practice.
  • Cost-effective screening models exist, targeting at-risk populations.
  • Validated educational resources and manageable ethical considerations are available.

Conclusions:

  • Prenatal CF screening can be initiated once essential infrastructure is established.
  • Key components include patient and provider education, testing, counseling, quality control, and monitoring.
Abstract

Keywords:
Genetics and Reproduction

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