Related Experiment Video
Updated: Sep 1, 2026
Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
Published on: November 24, 2014
Prognostic value of 201Tl myocardial scintigraphy after coronary artery bypass grafting
Insights
Thallium-201 SPECT can predict cardiac events in patients after coronary artery bypass grafting (CABG). The time since CABG and scintigraphy findings, like defect extent and lung uptake, are key predictors of future cardiac events.
Area of Science:
- Cardiology
- Nuclear Medicine
- Cardiovascular Surgery
Background:
- 201Tl myocardial scintigraphy (201Tl SPECT) is a valuable prognostic tool for coronary artery disease.
- Its utility in patients post-coronary artery bypass grafting (CABG) requires further assessment.
Purpose of the Study:
- To evaluate the prognostic value of stress 201Tl SPECT in patients who have undergone CABG.
- To determine the relationship between clinical data, stress 201Tl SPECT findings, and subsequent cardiac events in this population.
Main Methods:
- A study of 115 consecutive patients who underwent CABG was conducted.
- Clinical data and stress 201Tl SPECT were analyzed in relation to subsequent cardiac events over a mean follow-up of 35 months.
Main Results:
- Abnormal scintigraphy was observed in 84% of patients, with 54% showing reversible defects.
- Multivariate analysis identified the delay between CABG and scintigraphy, extent of 201Tl defects, and lung uptake as significant predictors of cardiac death/infarction.
- Delay between CABG and scintigraphy, extent of stress 201Tl defects, and reversible defects predicted total cardiac events.
Conclusions:
- Scintigraphic parameters, in addition to the delay between CABG and scintigraphy, are significant and additive predictors of cardiac events in patients with prior CABG.
- Stress 201Tl SPECT provides prognostic information in patients following CABG.
Background:
201Tl myocardial scintigraphy (201Tl SPECT) is of strong prognostic value in various populations with suspected or known coronary artery disease. However, its value in patients with coronary artery bypass grafting (CABG) is not fully assessed.
Methods:
We examined 115 consecutive patients to determine the relation between clinical data/stress 201Tl SPECT performed 5+/-3 years after CABG, and subsequent cardiac events.
Results:
Thirteen patients (11%) had stress-induced angina, 22 (19%) had electrical positivity, and 97 (84%) had abnormal scintigraphy, including 62 (54%) with reversible defects. During follow-up (35+/-22 months), there were nine cardiac deaths, seven myocardial infarctions, and 20 revascularization procedures. Multivariate Cox analysis identified the delay between CABG and scintigraphy (P<0.01, relative risk (RR) = 1.01), the extent of stress 201Tl defects (P = 0.04, RR = 1.18), and increased stress 201Tl lung uptake (P = 0.03, RR = 3.56) as significant predictors of cardiac deaths/infarctions. Delay between CABG and scintigraphy (P < 0.001, RR = 1.01), the extent of stress 201Tl defects (P = 0.03, RR = 1.15), and that of reversible defects (P = 0.05, RR = 1.13) were the only significant predictors of total events.
Conclusions:
Besides the delay between CABG and scintigraphy, the scintigraphic parameters were the only significant and additive predictors of cardiac events in 115 patients with CABG.
More Related Videos
09:12Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
05:25Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Related Concept Videos
01:28Imaging Studies for Cardiovascular System V: CT
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:30Acute Coronary Syndrome III: Diagnostic Studies