Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The ribosome at atomic resolution.

P B Moore1

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

Biochemistry
|March 22, 2001
PubMed
Summary
This summary is machine-generated.

Atomic resolution crystal structures of ribosomal subunits from Haloarcula marismortui and Thermus thermophilus are revolutionizing protein synthesis research. These groundbreaking structures significantly impact RNA biochemistry and experimental design for future studies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis.

Acta psychiatrica Scandinavica·2013
Same author

Endocannabinoid system dysfunction in mood and related disorders.

Acta psychiatrica Scandinavica·2011
Same author

Neurobiological characterization of bipolar affective disorders : a focus on tardive dyskinesia and soft neurological signs in relation to serum dopamine Beta hydroxylase activity.

Indian journal of psychiatry·2011
Same author

Climate change and the integrity of science.

Science (New York, N.Y.)·2010
Same author

White matter lesions in euthymic patients with bipolar disorder.

Acta psychiatrica Scandinavica·2009
Same author

Quaternary Organization of the 30S Ribosomal Subunit of Escherichia Coli.

Biophysical journal·2009
Same journal

Structural and Functional Characterization of Heterologous Nitrogenase Complexes.

Biochemistry·2026
Same journal

Discovery of Bacterial Unspecific Peroxygenases.

Biochemistry·2026
Same journal

Lactate Biology: Subcellular Routing and Chemical Form Define Function.

Biochemistry·2026
Same journal

Nature's Anaerobic Toolkit: Glycyl Radical Enzymes and Their Expanding Functional and Mechanistic Diversity.

Biochemistry·2026
Same journal

Structural Bases for the Unconventional Activity of a Viroporin Channel.

Biochemistry·2026
Same journal

Targeting the WASF3 Regulatory Complex in Pancreatic Cancer Using Stapled Peptides.

Biochemistry·2026
See all related articles

Area of Science:

  • Structural Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The advent of atomic resolution crystal structures for ribosomal subunits marks a significant advancement.
  • Understanding the ribosome's structure is crucial for deciphering protein synthesis mechanisms.

Purpose of the Study:

  • To review the background and substance of recent developments in ribosomal structure determination.
  • To highlight the profound impact of these structures on RNA biochemistry and protein synthesis research.

Main Methods:

  • X-ray crystallography was employed to determine the atomic resolution structures.
  • Analysis of crystal structures of the large ribosomal subunit (Haloarcula marismortui) and small ribosomal subunit (Thermus thermophilus).

Related Experiment Videos

Main Results:

  • Publication of atomic resolution crystal structures for both large and small ribosomal subunits.
  • These structures provide unprecedented insights into the ribosome's architecture and function.

Conclusions:

  • The determined ribosomal structures have fundamentally changed the conceptualization of protein synthesis.
  • The impact on RNA biochemistry and future experimental design is profound and far-reaching.