Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Angiogenesis in the placenta.

L P Reynolds1, D A Redmer

  • 1Department of Animal & Range Sciences, and Cell Biology Center, North Dakota State University, Fargo, North Dakota 58105-5727, USA. larry_reynolds@ndsu.nodak.edu

Biology of Reproduction
|March 22, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Review: Micronutrient supply, developmental programming, and strategic supplementation in ruminant livestock.

Animal : an international journal of animal bioscience·2025
Same author

International Symposium on Ruminant Physiology: Maternal nutrient supply-Impacts on physiological and whole-animal outcomes in offspring.

Journal of dairy science·2024
Same author

Role of the placenta in developmental programming: Observations from models using large animals.

Animal reproduction science·2023
Same author

Effect of ewe birth litter size and estimation of genetic parameters on ewe reproductive life traits.

Animal : an international journal of animal bioscience·2023
Same author

DOHaD: A MENAGERIE OF ADAPTATIONS AND PERSPECTIVES: Large animal models of developmental programming: sustenance, stress, and sex matter.

Reproduction (Cambridge, England)·2023
Same author

Effects of fetal and maternal genotype on placentome morphology in sheep.

Theriogenology·2020
Same journal

Reduced Circulating Polyamines in Polyendocrine Metabolic Ovarian Syndrome (PMOS) Patients and the Impact of Putrescine on Ovarian Function and Fertility in a Murine PMOS Model.

Biology of reproduction·2026
Same journal

DEVELOPMENTAL PROGRAMMING IN DOGS.

Biology of reproduction·2026
Same journal

Meiosis-Specific Cohesin in Mammalian Germ Cells.

Biology of reproduction·2026
Same journal

The Research of Lactylation in the Field of Reproduction.

Biology of reproduction·2026
Same journal

Mitochondria as Integrative Regulators of Ferroptosis in the Female Reproductive System.

Biology of reproduction·2026
Same journal

Retraction and replacement of: Navigation of Nanos germ cell specification factor to germ granules-posttranscriptional regulation hubs-across species.

Biology of reproduction·2026
See all related articles

Placental vascularization is crucial for fetal development, with vascular endothelial growth factors playing a key role in placental angiogenesis. Understanding these factors and their interaction with nitric oxide can improve high-risk pregnancy outcomes.

Area of Science:

  • Reproductive biology
  • Developmental biology
  • Physiology

Background:

  • The mammalian placenta facilitates vital nutrient, gas, and waste exchange between mother and fetus.
  • Transplacental exchange supports fetal growth and development, with blood flow rates being critical.
  • Reduced maternal placental blood flow is linked to fetal growth retardation and high-risk pregnancies.

Purpose of the Study:

  • To investigate the role of angiogenic factors in placental vascularization and blood flow.
  • To explore the mechanisms coordinating placental angiogenesis for healthy fetal development.
  • To identify potential therapeutic targets for improving pregnancy outcomes.

Main Methods:

  • Review of recent studies on placental angiogenesis, including gene knockout models in mice.

Related Experiment Videos

  • Analysis of the roles of vascular endothelial growth factors, fibroblast growth factors, and angiopoietins.
  • Examination of the interaction between angiogenic factors and nitric oxide in placental blood flow regulation.

    • Main Results:

    • Vascular endothelial growth factors are identified as major placental angiogenic factors.
    • Other factors like fibroblast growth factors and angiopoietins may also contribute to placental vascularization.
    • Angiogenic factors interact with nitric oxide to regulate placental angiogenesis and blood flow.

    Conclusions:

    • Placental angiogenesis is essential for successful fetal development and viable offspring.
    • Vascular endothelial growth factors are key regulators of placental vascularization.
    • Future development of angiogenesis regulators may offer novel strategies for managing high-risk pregnancies.