Celite-activated thrombelastography in children

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E G Pivalizza1, P J Pivalizza, L I Gottschalk

  • 1Department of Anesthesiology and School of Public Health, University of Texas Health Science Center-Houston, Houston, TX 77030, USA. Evan.G.Pivalizza@uth.tmc.edu

Journal of Clinical Anesthesia
|March 22, 2001
PubMed

Insights

This study established normal ranges for the celite-activated thrombelastograph (TEG) in children, finding minor coagulation differences compared to adults that do not indicate abnormal function.

Area of Science:

  • Pediatric Coagulation
  • Hemostasis Monitoring
  • Thrombelastography

Background:

  • Establishing normal hemostasis ranges in pediatric populations is crucial for accurate clinical interpretation.
  • The celite-activated thrombelastograph (TEG) is a valuable tool for assessing global coagulation.
  • Limited data exists on age-specific normal TEG values in healthy children.

Purpose of the Study:

  • To quantify global coagulation using the celite-activated TEG.
  • To establish normal reference ranges for celite-activated TEG parameters in healthy pediatric patients across different age groups.
  • To compare pediatric TEG values with those of healthy adults.

Main Methods:

  • A prospective observational study was conducted in a university hospital setting.
  • 110 healthy pediatric patients (categorized into four age groups) and 25 healthy adults were enrolled.
  • Blood samples were analyzed using celite-activated TEG after anesthetic induction, measuring R time, K time, alpha angle, maximum amplitude, TEG index, and percent fibrinolysis.

Main Results:

  • Statistically significant differences were observed in alpha angle and percent fibrinolysis between certain pediatric age groups.
  • Significant differences in angle and TEG index were found when comparing pediatric groups to the adult group (p < 0.05).
  • These observed changes were of small magnitude and not consistently age-related.

Conclusions:

  • The study identified minor variations in celite-TEG parameters in healthy children compared to adults.
  • These differences do not suggest abnormal coagulation between the pediatric and adult groups.
  • The established normal ranges will aid clinicians in monitoring coagulation status in pediatric patients.
Abstract

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