Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regional anesthesia and anticoagulation.

C L Wu1

  • 1Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital, Baltimore, MD 21287, USA. chu@jhmi.edu

Journal of Clinical Anesthesia
|March 22, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Clinical application effects of the "three-source and four-line method" in the design and harvest of anterolateral lower leg perforator flaps].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2026
Same author

Editorial Expression of Concern: Role of AMPK in UVB-induced DNA damage repair and growth control.

Oncogene·2026
Same author

[Monomorphic epitheliotropic intestinal T-cell lymphoma: a clinicopathological and genetic mutation characteristics analysis of forty-two cases].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2025
Same author

Fast STEM image simulation in low-energy transmission electron microscopy by the accurate Chen-van-Dyck multislice method.

Micron (Oxford, England : 1993)·2024
Same author

Lattice distortion enabling enhanced strength and plasticity in high entropy intermetallic alloy.

Nature communications·2024
Same author

[Application of three dimensional printed personalized guide plate assisted arthroscopic ankle arthrodesis in the treatment of ankle arthritis].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2024
Same journal

NRFit connectors: Implementation after the engineering solution.

Journal of clinical anesthesia·2026
Same journal

Retraction notice to 'The effect of play distraction on anxiety prior to pre-medication administration: A randomized trial' [Journal of Clinical Anesthesia 36 (2017) 27-31].

Journal of clinical anesthesia·2026
Same journal

Sodium bicarbonate alkalinization of local anesthetics for peripheral nerve blocks: A systematic review.

Journal of clinical anesthesia·2026
Same journal

Dynamic changes in oxygen-hemoglobin affinity during liver transplantation.

Journal of clinical anesthesia·2026
Same journal

AI-assisted interpretation of arterial blood gases using a hybrid Stewart and standard base excess model.

Journal of clinical anesthesia·2026
Same journal

Corrigendum to "Effect of midodrine on orthostatic intolerance after hip and knee arthroplasty: A randomized controlled trial (the MOBiLE study)" [Journal of Clinical Anesthesia, Volume 113 (2026), 112261].

Journal of clinical anesthesia·2026
See all related articles

Perioperative neuraxial techniques are controversial with anticoagulation due to drug differences. This review examines anticoagulant pharmacokinetics and neuraxial procedures, referencing expert guidelines for safe practice.

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Neuraxial techniques (e.g., epidural, spinal) are common for surgical anesthesia and analgesia.
  • Perioperative anticoagulation is frequently used to prevent thromboembolic events.
  • Concurrent use of anticoagulation and neuraxial procedures presents a risk of spinal hematoma.

Purpose of the Study:

  • To review the pharmacokinetic profiles of commonly used perioperative anticoagulants.
  • To evaluate the safety and timing of neuraxial needle insertion and catheter removal in patients on anticoagulation.
  • To contextualize findings within the American Society of Regional Anesthesia (ASRA) consensus statements.

Main Methods:

  • Literature review of pharmacologic profiles of anticoagulants.
  • Review and analysis of studies on neuraxial techniques with various anticoagulants.

Related Experiment Videos

  • Comparison of findings with existing ASRA consensus guidelines.

    • Main Results:

    • Significant pharmacokinetic variability exists among anticoagulants, influencing safe neuraxial timing.
    • Evidence supports specific management strategies based on anticoagulant type and duration.
    • ASRA guidelines provide a framework for risk mitigation.

    Conclusions:

    • Informed decisions regarding neuraxial techniques in anticoagulated patients require understanding drug-specific pharmacokinetics.
    • Adherence to evidence-based guidelines, such as ASRA's, is crucial for patient safety.
    • Further research may refine optimal management protocols.