Related Experiment Video
Updated: Oct 9, 2026

Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
The retinoblastoma family member, p107, is active in non-dividing monocyte-derived dendritic cells
K M Ardeshna1, F Ahmed, S Devereux
1Department of Haematology, Royal Free and University College London Medical School, London WC1E 6HX, UK. kirit.ardeshna@gosh-tr.nthames.nhs.uk
Abstract:
A member of the retinoblastoma family of cell cycle regulatory proteins, p107, is not normally expressed in non-cycling cells. We demonstrate here that p107 is expressed in monocytes as they differentiate into dendritic cells under the influence of granulocyte-macrophage colony-stimulating factor and interleukin 4, a process shown not to involve cellular proliferation. We show that p107 is localized to the nucleus of these cells and is active, in that it binds an E2F-DNA binding site, together with E2F transcription factors. These findings suggest a hitherto unknown role for p107 in non-proliferating dendritic cells that warrants further investigation.
Related Concept Videos
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Negative Regulator Molecules
Abnormal Proliferation
The Ras Gene
Ras is a superfamily...
Inhibition of Cdk Activity

