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Related Experiment Videos

Fixed drug eruption due to clarithromycin.

Y Hamamoto1, A Ohmura, E Kinoshita

  • 1Department of Dermatology, Yamaguchi University School of Medicine, Ube Yamaguchi, Japan.

Clinical and Experimental Dermatology
|March 22, 2001
PubMed
Summary

A rare case of clarithromycin-induced fixed drug eruption is presented. The reaction was confirmed by oral challenge, but not by patch testing, highlighting a unique diagnostic challenge for this antibiotic.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Infectious Diseases

Background:

  • Clarithromycin, a macrolide antibiotic, is widely used for bacterial infections.
  • Adverse cutaneous reactions to clarithromycin are infrequently reported.
  • Fixed drug eruptions (FDEs) are a type of adverse drug reaction characterized by recurrent lesions at the same site.

Observation:

  • This report details a rare case of fixed drug eruption caused by clarithromycin.
  • The patient experienced recurrent skin lesions upon oral administration of clarithromycin.
  • Diagnostic evaluation included peroral provocation testing and patch testing.

Findings:

  • Peroral provocation with clarithromycin successfully reproduced the fixed drug eruption.
  • Patch tests, performed on both unaffected and previously affected pigmented skin, yielded negative results.

Related Experiment Videos

  • Cutaneous lesions from the challenge test showed similar pigmentation after corticosteroid treatment.

    • Implications:

    • This case underscores the importance of considering FDEs even with rare reported instances.
    • The negative patch test results suggest limitations in standard diagnostic methods for certain drug-induced FDEs.
    • Oral provocation remains a valuable, albeit invasive, tool for diagnosing challenging drug eruptions.