Two sporadic cases of idiopathic multiple minute digitate hyperkeratosis
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Updated: Sep 27, 2026

Generation and Culturing of Primary Human Keratinocytes from Adult Skin
Published on: December 22, 2017
P Rubegni1, G De Aloe, E Pianigiani
1Istituto di Scienze Dermatologiche, Siena University, Italy.
Abstract:
Multiple minute digitate hyperkeratosis (MMDH) is a skin disease of unknown aetiology characterized clinically by multiple minute asymptomatic keratotic lesions with spiky horny projections. The disorder has been classified into early (congenital) and late (acquired) onset forms, the latter occurring as a presenting sign of concomitant inflammatory, metabolic or malignant disease. Here we report two cases of late onset MMDH without any associated pathology. These cases emphasize that some cases of late-onset MMDH may be idiopathic.
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