Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fatal overdose from Bendectin.

M Bayley, F M Walsh, M J Valaske

    Clinical Pediatrics
    |May 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    A child experienced seizures and cardiac arrest after ingesting 100 Bendectin tablets. High levels of doxylamine succinate, an antihistamine, were identified as the likely toxic agent in this overdose case.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Age-specific information resources to address the needs of young people with stroke: a scoping review protocol.

    Systematic reviews·2022
    Same author

    Nitrogen processing by treatment wetlands in a tropical catchment dominated by agricultural landuse.

    Marine pollution bulletin·2021
    Same author

    Best practice for arm recovery post stroke: an international application.

    Physiotherapy·2015
    Same author

    Increased temperature tolerance of the air-breathing Asian swamp eel Monopterus albus after high-temperature acclimation is not explained by improved cardiorespiratory performance.

    Journal of fish biology·2015
    Same author

    Measuring oxygen uptake in fishes with bimodal respiration.

    Journal of fish biology·2015
    Same author

    Do measures of reactive balance control predict falls in people with stroke returning to the community?

    Physiotherapy·2015
    Same journal

    Effect of Preferred Language on Pediatric Rapid Response Activation and Subsequent Intensive Care Utilization.

    Clinical pediatrics·2026
    Same journal

    Documented Caregiver Report of Wheezing at Home is Associated With Decreased Length of Pediatric Asthma Hospitalizations.

    Clinical pediatrics·2026
    Same journal

    The Rash That Will Not Go Away.

    Clinical pediatrics·2026
    Same journal

    Virtual Reality Education for Hospitalized Pediatric Patients Improves Intrinsic Motivation: A Prospective, Randomized Crossover Study.

    Clinical pediatrics·2026
    Same journal

    Pediatric Invasive Group A Streptococcus Characteristics Before, During, and After COVID-19.

    Clinical pediatrics·2026
    Same journal

    Lichen Sclerosus: A Common but Often Overlooked Condition in Pediatric Patients.

    Clinical pediatrics·2026
    See all related articles

    Area of Science:

    • Toxicology
    • Pharmacology
    • Pediatric Emergency Medicine

    Background:

    • Bendectin, a medication historically used for nausea and vomiting during pregnancy, contains doxylamine succinate, dicyclomine, and pyridoxine.
    • Overdose cases involving Bendectin are rare, necessitating detailed toxicological investigation.

    Observation:

    • A three-year-old male presented with tonic-clonic seizures and subsequent cardiac arrest after ingesting approximately 100 Bendectin tablets.
    • Postmortem toxicologic analysis revealed significantly elevated concentrations of doxylamine, dicyclomine, and pyridoxine.

    Findings:

    • The antihistamine component, doxylamine succinate, was identified as the primary toxic agent responsible for the adverse events.
    • High levels of doxylamine were detected in blood, peritoneal fluid, and tissue homogenates, confirming systemic toxicity.

    Related Experiment Videos

    Implications:

    • This case highlights the potential toxicity of doxylamine succinate in massive overdose scenarios.
    • The findings underscore the importance of prompt toxicologic analysis and supportive care in pediatric overdose emergencies.
    • Accurate analytical methods are crucial for documenting and understanding the toxicological profile of ingested substances.