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Lignans from Kadsura angustifolia.
1Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China.
Journal of Asian Natural Products Research
|March 23, 2001
Summary
Researchers isolated five lignans from Kadsura angustifolia stems, including a new compound, angustifolin D. Two known lignans exhibited moderate platelet-activating factor (PAF) antagonistic activity.
Area of Science:
- Natural Products Chemistry
- Pharmacology
Background:
- Kadsura angustifolia is a plant species known for its diverse chemical constituents.
- Lignans are a class of phenolic compounds with a wide range of biological activities.
Purpose of the Study:
- To isolate and characterize chemical constituents from Kadsura angustifolia stems.
- To evaluate the isolated compounds for platelet-activating factor (PAF) antagonistic activity.
Main Methods:
- Phytochemical investigation involving isolation techniques.
- Structure elucidation using spectral studies (e.g., NMR, MS).
- In vitro assays to determine PAF antagonistic activity.
Main Results:
- A new dibenzocyclooctadiene lignan, angustifolin D, was identified.
- Four known lignans, kadsulignan L, kadsulignan N, schisantherin P, and meso-dihydroguaiaretic acid, were also isolated.
- Kadsulignan L and meso-dihydroguaiaretic acid demonstrated moderate PAF antagonistic effects with IC50 values of 2.6 x 10(-5) M and 4.1 x 10(-5) M, respectively.
Conclusions:
- The study successfully identified novel and known lignans from Kadsura angustifolia.
- The findings suggest potential therapeutic applications for these lignans in conditions involving PAF, such as inflammation and thrombosis.