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Fluconazole dose recommendation in urinary tract infection

K S Boedeker1, W J Kilzer

  • 1College of Pharmacy, The University of Texas at Austin, USA.

The Annals of Pharmacotherapy
|March 23, 2001
PubMed
Abstract

Insights

For symptomatic fungal urinary tract infections (UTIs), a fluconazole loading dose of 200 mg followed by 100 mg daily for four days is recommended. This dosage is suggested for patients without severe systemic fungal infections or renal failure.

Area of Science:

  • Mycology
  • Pharmacology
  • Infectious Diseases

Background:

  • Fungal urinary tract infections (UTIs) are often treated with fluconazole.
  • Current dosage recommendations for fluconazole in treating candidal UTIs are inconsistent.

Purpose of the Study:

  • To determine the optimal fluconazole dosage for treating symptomatic fungal UTIs.
  • To evaluate existing clinical data on fluconazole efficacy for candidal UTIs.

Main Methods:

  • A comprehensive literature search was conducted using MEDLINE from 1990 to June 2000.
  • Key search terms included "fluconazole" and "urinary tract infection."

Main Results:

  • Fluconazole is an approved treatment for candidal UTIs.
  • Analysis of clinical studies revealed variability in recommended fluconazole dosages.

Conclusions:

  • Optimal fluconazole dosing, particularly for non-albicans Candida species and therapy duration, requires further investigation.
  • A regimen of a 200-mg loading dose followed by 100 mg daily for at least four days is proposed as the most appropriate treatment for symptomatic candidal UTIs in patients without systemic complications or severe renal impairment.

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