Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Iminopropadienethiones, Ar=N=C=C=C=S.

C O Kappe1, D Kvaskoff, D W Moloney

  • 1Department of Chemistry, The University of Queensland, Brisbane, Qld. 4072, Australia.

The Journal of Organic Chemistry
|March 23, 2001
PubMed
Summary

New aryliminopropadienethiones were synthesized via flash vacuum thermolysis of isoxazolones. These compounds were then characterized using advanced spectroscopic and computational techniques.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase dependent encapsulation and release profile of ZIF-based biocomposites.

Chemical science·2021
Same author

Acquisition of a Novel Sulfur-Oxidizing Symbiont in the Gutless Marine Worm Inanidrilus exumae.

Applied and environmental microbiology·2018
Same author

Differential Regulation of Eicosanoid and Endocannabinoid Production by Inflammatory Mediators in Human Choriodecidua.

PloS one·2016
Same author

The vinylketene-acylallene rearrangement: theory and experiment.

Chemistry (Weinheim an der Bergstrasse, Germany)·2013
Same author

Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways.

British journal of pharmacology·2012
Same author

Letter: OCCO*+, NNCO*+ and NNNN*+ radical cations.

European journal of mass spectrometry (Chichester, England)·2007

Area of Science:

  • Organic Chemistry
  • Spectroscopy
  • Computational Chemistry

Background:

  • The synthesis of novel organic compounds is crucial for advancing chemical science.
  • Flash vacuum thermolysis is a powerful technique for generating reactive intermediates.
  • Isoxazolones serve as versatile precursors in organic synthesis.

Purpose of the Study:

  • To synthesize and characterize aryliminopropadienethiones.
  • To explore the utility of isoxazolones as precursors for these compounds.
  • To investigate the properties of the newly synthesized molecules.

Main Methods:

  • Flash vacuum thermolysis of substituted isoxazolones.
  • Mass spectrometry for molecular weight determination.
  • Matrix isolation infrared (IR) spectroscopy for structural elucidation.

Related Experiment Videos

  • Density Functional Theory (DFT) calculations for theoretical analysis.
  • Chemical trapping experiments to confirm reactivity.

    • Main Results:

    • Successful generation of aryliminopropadienethiones (9) from isoxazolones (5).
    • Characterization data confirmed the formation of the target compounds.
    • Spectroscopic and computational methods provided detailed structural information.
    • Chemical trapping indicated the reactive nature of the synthesized molecules.

    Conclusions:

    • Aryliminopropadienethiones can be effectively synthesized using flash vacuum thermolysis of isoxazolones.
    • A combination of experimental and theoretical methods is essential for characterizing such reactive species.
    • This study expands the scope of accessible sulfur-containing organic compounds.