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Updated: Aug 26, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
[Evolutionary theories on schizophrenia]
1Unidad de Psiquiatría, Departamento de Medicina, Avda. Blasco Ibáñez, Valencia. julio.sanjuan@uv.es
Abstract:
The universal distribution of schizophrenia associated with the low fertility of these patients outlines the paradox: why doesn't diminish the prevalence of this dysfunction? A critical revision is made of the main hypotheses that have thought about to solve this question. Some theories have postulated a physiologic or social advantage. Others have analysed this illness from the mark of the Evolutionary Psychology. We stand out the theories that have looked for an association of a Darwinian approach with genetic or neurodevelopmental data. Finally a possibility of integration of the evolutionary and neuropsychological models is proposed.
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